^{1 Doxycycline hyclate is ~87% doxycycline
2 TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation}

• • Teklad Global Rodent Diets® like 2018 do not contain alfalfa and are thus ideal if your work requires an alfalfa-free diet for fluorescent imaging, If further imaging clarity is needed, we can make purified diets with doxycycline.
  • Teklad global 2018 (base diet in examples above) contains a moderate amount of soybean meal, a source of phytoestrogens. The table below includes several options of minimal phytoestrogen diets with the most common doxycycline concentration of 625 mg/kg diet. For other concentrations contact us. For additional phytoestrogen information, see our list of phytoestrogen references.

^{1 Doxycycline hyclate is ~87% doxycycline}

• Typically the same doxycycline concentration can be used in diet as in water. Lower concentrations of doxycycline may be adequate with 625 mg/kg diet being the most common concentration.
• Diet offers protection from light. Water may have to be given in dark-colored or foil-wrapped bottles
• Diet is typically changed once per week. Water may need to be changed every few days
• Diet delivery may also reduce risk of dehydration and preclude the need to give with sucrose (Cawthorne et. al. 2007)

• Minimum order quantity is 3 kg, sufficient for feeding ~20 mice for one month
• Store diet refrigerated and plan to use within six months
• Typical lead time is two weeks (four weeks if irradiated)
  • TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation
• Irradiation (20 – 50 kGy) is optional, and must be requested at time of order

• Doxycycline is a tetracycline class antibiotic.
• Usual dose for therapeutic effects in humans is 100-200 mg/day. Doxycycline diets for rodents typically contain ~2 mg/pellet.
• Accidental doxycycline exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
• Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of doxycycline containing diets.