Prostaglandin E2
货号：C363246
规格：20mg
品牌：OrganRegen
产品介绍
DESCRIPTION
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Background |
Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. |
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Alias |
PGE2；前列腺素 E2；地诺前列酮 |
技术参数
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M. W t |
352.47 |
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Formula |
C₂₀H₃₂O₅ |
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CAS No |
363-24-6 |
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Storage |
Powder |
-20°C 3 years |
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In solvent |
-80°C 6 months |
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-20°C 1 month |
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Solubility |
DMSO |
≥ 100 mg/mL(283.71 mM) |
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Ethanol |
70 mg/mL(198.60 mM) |
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H2O |
< 0.1 mg/mL(insoluble) |
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BIOLOGICAL ALTIVITY
PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].
In Vivo
PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats[2]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[3].
REFERENCES