属性
质量水平
200
形式
viscous liquid
分子量
average Mn~10,000 by GPC
average Mw~25,000 by LS
杂质
≤1% water
折射率
n20/D 1.5290
粘度
13,000-18,000(50°C)
bp
250°C (lit.)
密度
1.030g/mLat 25°C
SMILES string
C1CN1
InChI
1S/C2H5N/c1-2-3-1/h3H,1-2H2
InChI key
NOWKCMXCCJGMRR-UHFFFAOYSA-N
说明
一般描述
Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.
应用
用作带电表面上的聚电解质多层膜，为该表面提供生物相容涂层。[1]
洗涤剂、粘合剂、水处理、油墨、染料、化妆品、造纸业、助粘剂、层压底漆、固色剂、絮凝剂、阳离子分散剂、稳定增强剂、表面活性剂、螯合剂以及醛类和氧化物清除剂。
Polyethyleneimine can be used as a non-viral synthetic polymer vector forin vivodelivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.
PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2absorption and gene delivery.
Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.
包装
100, 250 mL in poly bottle
1 L in poly bottle
特点和优势
Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties.
Branched PEI has better complexation andbuffering capacity.
外形
支化聚合物