Hydrocortisone
货号：C502370
规格：500mg
品牌：OrganRegen
产品介绍
DESCRIPTION
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Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1]. |
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Alias |
Cortisol；氢化可的松；17-羟基皮质 (甾) 酮；皮质甾醇；氢化皮质素 |
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M. W t |
362.46 |
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Formula |
C21H30O5 |
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CAS No |
50-23-7 |
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Storage |
Powder |
-20 °C |
3 years |
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In solvent |
-80 °C |
6 months |
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-20 °C |
1 month |
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Solubility |
DMSO H2O : < 0.1 mg/mL |
≥ 31 mg/mL(85.53 mM)
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Ethanol |
23 mg/mL(63.46 mM) |
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H2O |
< 0.1 mg/mL(insoluble) |
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BIOLOGICAL ALTIVITY
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
In Vivo
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Boston Children´s Hospital |
Adrenal Hyperplasia, Congenital |
Phase 2 |
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NCT03910088 |
Cairo University |
Post-Dural Puncture Headache |
Phase 4 |
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NCT00657306 |
University of Turin, Italy |
Cirrhosis With Ascites |
Phase 2 |
REFERENCES