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PCNA Mouse Monoclonal Antibody [Clone ID: OTI2G7]PCNA小鼠单克隆抗体[克隆ID：OTI2G7]

发表于由
Product Data
Clone Name OTI2G7
Applications IF, WB
Recommend Dilution WB 1:2000, IF 1:50
Reactivity Human, Monkey, Mouse, Rat, Dog
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PCNA (NP_002583) produced in E.coli.
Isotype IgG2b
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 28.6 kDa
Gene Name proliferating cell nuclear antigen
Background The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
 Reference Data
Protein Families Druggable Genome, Stem cell – Pluripotency
Protein Pathways Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

The use of this Antibodies has been cited in the following citations:
Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway ,Li, L;Wu, B;Zhao, Q;Li, J;Han, Y;Fan, X;Dong, J;Li, P;, Aging (Albany NY) 2020 ,PubMed ID 32457254 [PCNA]
Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model ,Wu, B;Huang, XY;Li, L;Fan, XH;Li, PC;Huang, CQ;Xiao, J;Gui, R;Wang, S;, J. Cell. Mol. Med. 2019 ,PubMed ID 31565849 [PCNA]
Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage ,Pond, KW;de Renty, C;Yagle, MK;Ellis, NA;, PLoS Genet. 2019 ,PubMed ID 30735491 [PCNA]
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α ,Wang, Q;He, Z;Huang, M;Liu, T;Wang, Y;Xu, H;Duan, H;Ma, P;Zhang, L;Zamvil, SS;Hidalgo, J;Zhang, Z;O'Rourke, DM;Dahmane, N;Brem, S;Mou, Y;Gong, Y;Fan, Y;, Nat Commun 2018 ,PubMed ID 29422647 [PCNA]
Modulation of liver regeneration via myeloid PTEN deficiency ,Ma, WT;Jia, YJ;Liu, QZ;Yang, YQ;Yang, JB;Zhao, ZB;Yang, ZY;Shi, QH;Ma, HD;Gershwin, ME;Lian, ZX;, Cell Death Dis 2017 ,PubMed ID 28542148 [PCNA]
Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma ,Liu, TT;You, HL;Weng, SW;Wei, YC;Eng, HL;Huang, WT;, PLoS ONE Dec 2015 ,PubMed ID 26684807 [PCNA]

HSP90AB1 Mouse Monoclonal Antibody [Clone ID: OTI4C10]HSP90AB1 小鼠单克隆抗体 [克隆 ID： OTI4C10]

发表于由
 Product Data
Clone Name OTI4C10
Applications WB
Recommend Dilution WB 1:2000
Reactivity Human, Monkey, Mouse, Rat, Dog
Host Mouse
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human HSP90AB1 expression vector
Isotype IgG2b
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 83.3 kDa
Gene Name heat shock protein 90 alpha family class B member 1
Background HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219)
 Reference Data
Protein Families Druggable Genome, Stem cell – Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

The use of this Antibodies has been cited in the following citations:
An Exploratory Analysis of Extracellular Vesicle-Associated and Soluble Cytokines in Cancer-Related Fatigue in Men with Prostate Cancer. ,Sass, D;Fitzgerald, W;Barb, J;Kupzyk, K;Margolis, L;Saligan, L;, Brain, Behavior, & Immunity – Health 2020 [HSP90AB1]
Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy ,Hossain, M;Williams, S;Ferguson, L;Bingaman, W;Ghosh, A;Najm, IM;Ghosh, C;, Mol. Neurobiol. 2020 ,PubMed ID 32748370 [HSP90AB1]
LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway ,Li, HK;Zhou, Y;Ding, J;Xiong, L;Shi, YX;He, YJ;Yang, D;Deng, ZL;Nie, M;Fei Gao, Y;, Exp. Cell Res. 2020 ,PubMed ID 32841643 [HSP90AB1]
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas ,Florkowska, A;Meszka, I;Zawada, M;Legutko, D;Proszynski, TJ;Janczyk-Ilach, K;Streminska, W;Ciemerych, MA;Grabowska, I;, Stem Cell Res Ther 2020 ,PubMed ID 32552916 [HSP90AB1]
In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo ,Aprile, M;Cataldi, S;Perfetto, C;Ambrosio, MR;Italiani, P;Tatè, R;Blüher, M;Ciccodicola, A;Costa, V;, Cells 2020 ,PubMed ID 32455814 [HSP90AB1]
Superoxide Dismutases SOD1 and SOD2 Rescue the Toxic Effect of Dopamine-Derived Products in Human SH-SY5Y Neuroblastoma Cells ,Biosa, A;De Lazzari, F;Masato, A;Filograna, R;Plotegher, N;Beltramini, M;Bubacco, L;Bisaglia, M;, Neurotox Res 2019 ,PubMed ID 31228093 [HSP90AB1]
Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage ,Pond, KW;de Renty, C;Yagle, MK;Ellis, NA;, PLoS Genet. 2019 ,PubMed ID 30735491 [HSP90AB1]
Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life ,Trepotec, Z;Geiger, J;Plank, C;Aneja, MK;Rudolph, C;, RNA 2019 ,PubMed ID 30647100 [HSP90AB1]
Tamoxifen therapy in a murine model of myotubular myopathy ,Maani, N;Sabha, N;Rezai, K;Ramani, A;Groom, L;Eltayeb, N;Mavandadnejad, F;Pang, A;Russo, G;Brudno, M;Haucke, V;Dirksen, RT;Dowling, JJ;, Nat Commun 2018 ,PubMed ID 30451841 [HSP90]
Chromatin regulates IL-33 release and extracellular cytokine activity ,Travers, J;Rochman, M;Miracle, CE;Habel, JE;Brusilovsky, M;Caldwell, JM;Rymer, JK;Rothenberg, ME;, Nat Commun 2018 ,PubMed ID 30108214 [HSP90AB1]
MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1 ,Liang, W;Liao, Y;Li, Z;Wang, Y;Zheng, S;Xu, X;Ran, F;Tang, B;Wang, Z;, Cell Commun. Signal 2018 ,PubMed ID 29898735 [HSP90AB1]
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells ,Ghosh, A;Garee, G;Sweeny, EA;Nakamura, Y;Stuehr, DJ;, Proc. Natl. Acad. Sci. U.S.A. 2018 ,PubMed ID 29358373 [HSP90AB1]
IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis ,Travers, J;Rochman, M;Caldwell, JM;Besse, JA;Miracle, CE;Rothenberg, ME;, Sci Rep 2017 ,PubMed ID 29242581 [HSP90AB1]
Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle ,Helinska, A;Krupa, M;Archacka, K;Czerwinska, AM;Streminska, W;Janczyk-Ilach, K;Ciemerych, MA;Grabowska, I;, Eur. J. Cell Biol 2016 ,PubMed ID 28017376 [HSP90AB1]
Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7 ,Czerwinska, AM;Nowacka, J;Aszer, M;Gawrzak, S;Archacka, K;Fogtman, A;Iwanicka-Nowicka, R;Janczyk-Ilach, K;Koblowska, M;Ciemerych, MA;Grabowska, I;, Cell Cycle 2016 ,PubMed ID 27610933 [Hsp90]

GAPDH Mouse Monoclonal Antibody [Clone ID: OTI2D9]GAPDH小鼠单克隆抗体[克隆ID：OTI2D9]

发表于由
Product Data
Clone Name OTI2D9
Applications WB
Recommend Dilution WB 1:2000
Reactivity Human, Monkey, Mouse, Rat, Dog
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human GAPDH (NP_002037) produced in HEK293T cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 35.9 kDa
Gene Name glyceraldehyde-3-phosphate dehydrogenase
Background The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
 Reference Data
Protein Families ES Cell Differentiation/IPS
Protein Pathways Alzheimer's disease, Glycolysis / Gluconeogenesis, Metabolic pathways

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

The use of this Antibodies has been cited in the following citations:
Progressive Characterization of Visual Phenotype in Bardet-Biedl Syndrome Mutant Mice ,Kretschmer, V;Patnaik, SR;Kretschmer, F;Chawda, MM;Hernandez-Hernandez, V;May-Simera, HL;, Invest. Ophthalmol. Vis. Sci. 2019 ,PubMed ID 30901771 [GAPDH]
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation ,Zhao, B;Chen, Y;Jiang, N;Yang, L;Sun, S;Zhang, Y;Wen, Z;Ray, L;Liu, H;Hou, G;Lin, X;, Nat Commun 2019 ,PubMed ID 30842416 [GAPDH]
SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary ,Di Emidio, G;Santini, SJ;D'Alessandro, AM;Vetuschi, A;Sferra, R;Artini, PG;Carta, G;Falone, S;Amicarelli, F;Tatone, C;, Biochim Biophys Acta Mol Basis Dis 2019 ,PubMed ID 30771486 [GAPDH]
MicroRNA-Based Prophylaxis in a Mouse Model of Cirrhosis and Liver Cancer ,Callegari, E;Domenicali, M;Shankaraiah, RC;D'Abundo, L;Guerriero, P;Giannone, F;Baldassarre, M;Bassi, C;Elamin, BK;Zagatti, B;Ferracin, M;Fornari, F;Altavilla, G;Blandamura, S;Silini, EM;Gramantieri, L;Sabbioni, S;Negrini, M;, Mol Ther Nucleic Acids 2018 ,PubMed ID 30641476 [GAPDH]
Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease ,Gentili, M;Ronchetti, S;Ricci, E;Di Paola, R;Gugliandolo, E;Cuzzocrea, S;Bereshchenko, O;Migliorati, G;Riccardi, C;, Pharmacol. Res. 2018 ,PubMed ID 30552973 [GAPDH]
Muscle activity prevents the uncoupling of mitochondria from Ca2+ release units induced by ageing and disuse ,Pietrangelo, L;Michelucci, A;Ambrogini, P;Sartini, S;Guarnier, FA;Fusella, A;Zamparo, I;Mammucari, C;Protasi, F;Boncompagni, S;, Arch. Biochem. Biophys. 2018 ,PubMed ID 30578752 [GAPDH]
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection ,Plitnik, T;Sharkey, M;Mahboubi, B;Kim, B;Stevenson, M;, PAI 2018 [GAPDH]
An AAV dual vector strategy ameliorates the Stargardt phenotype in adult Abca4-/- mice ,McClements, ME;Barnard, AR;Singh, MS;Charbel Issa, P;Jiang, Z;Radu, RA;MacLaren, RE;, Hum. Gene Ther. 2018 ,PubMed ID 30381971 [GAPDH]
Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway ,Wu, J;Zhang, C;Liu, C;Zhang, A;Li, A;Zhang, J;Zhang, Y;, Mol Med Rep 2018 ,PubMed ID 30431106 [GAPDH]
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4 ,Russo, I;Di Benedetto, G;Kaganovich, A;Ding, J;Mercatelli, D;Morari, M;Cookson, MR;Bubacco, L;Greggio, E;, J Neuroinflammation 2018 ,PubMed ID 30368241 [GAPDH]
Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation ,Maronde, E;, Front Mol Neurosci 2018 ,PubMed ID 30405349 [GAPDH]
The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC-27 Cells ,Wan, X;Shi, L;Ma, X;Tang, H;Wu, G;, Anat Rec (Hoboken) 2018 ,PubMed ID 30324658 [GAPDH]
Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters ,Yang, J;Zhang, B;Qin, Z;Li, S;Xu, J;Yao, Z;Zhang, X;Gonzalez, FJ;Yao, X;, Biofactors 2018 ,PubMed ID 30334318 [GAPDH]
Sucrosomial® Iron Supplementation in Mice: Effects on Blood Parameters, Hepcidin, and Inflammation ,Asperti, M;Gryzik, M;Brilli, E;Castagna, A;Corbella, M;Gottardo, R;Girelli, D;Tarantino, G;Arosio, P;Poli, M;, Nutrients 2018 ,PubMed ID 30241424 [GAPDH]
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis ,Wang, X;Buechler, NL;Long, DL;Furdui, CM;Yoza, BK;McCall, CE;Vachharajani, V;, Inflammation 2018 ,PubMed ID 30203196 [GAPDH]
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells ,Li, S;Xu, J;Yao, Z;Hu, L;Qin, Z;Gao, H;Krausz, KW;Gonzalez, FJ;Yao, X;, Chem. Biol. Interact. 2018 ,PubMed ID 30237061 [GAPDH]
Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer ,Liu, X;Wei, X;Niu, W;Wang, D;Wang, B;Zhuang, H;, Mol Med Rep 2018 ,PubMed ID 30221666 [GAPDH]
Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8 ,Schmidt, JA;Danielson, KG;Duffner, ER;Radecki, SG;Walker, GT;Shelton, A;Wang, T;Knepper, JE;, BMC Cancer 2018 ,PubMed ID 30041613 [GAPDH]
The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level ,Kwon, E;Todorova, K;Wang, J;Horos, R;Lee, KK;Neel, VA;Negri, GL;Sorensen, PH;Lee, SW;Hentze, MW;Mandinova, A;, Nat Commun 2018 ,PubMed ID 29712925 [GAPDH]
Aniseed ( Pimpinella anisum L.) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines ,Iannarelli, R;Marinelli, O;Morelli, M;Santoni, G;Amantini, C;Nabissi, M;Maggi, F;, Industrial Crops and Products 2018 [GAPDH]
SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules ,Wang, F;Zheng, L;Yi, Y;Yang, Z;Qiu, Q;Wang, X;Yan, W;Bai, P;Yang, J;Li, D;Pei, H;Niu, T;Ye, H;Nie, C;Hu, Y;Yang, S;Wei, Y;Chen, L;, Mol. Cancer Ther. 2018 ,PubMed ID 29610282 [GAPDH]
Identification of Miro as a mitochondrial receptor for myosin XIX ,Bähler, M;Oeding, S;Majstrowicz, K;Hu, X;Schwarz, V;Freitag, A;Honnert, U;Nikolaus, P;, bioRxiv 2018 [GAPDH]
NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniae ,Zheng, Y;Shang, F;An, L;Zhao, H;Liu, X;, Neurosci. Lett. 2018 ,PubMed ID 29408491 [GAPDH]
SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis ,Du, X;Pan, Z;Li, Q;Liu, H;Li, Q;, Cell Death Dis 2018 ,PubMed ID 29396446 [GAPDH]
Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation ,Habibian, M;Yahyaee-Anzahaee, M;Lucic, M;Moroz, E;Martín-Pintado, N;Di Giovanni, LD;Leroux, JC;Hall, J;González, C;Damha, MJ;, Nucleic Acids Res. 2018 ,PubMed ID 29373740 [GAPDH]
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity ,Sorrentino, V;Romani, M;Mouchiroud, L;Beck, JS;Zhang, H;D'Amico, D;Moullan, N;Potenza, F;Schmid, AW;Rietsch, S;Counts, SE;Auwerx, J;, Nature 2017 ,PubMed ID 29211722 [GAPDH]
Effect of miR-204&211 and RUNX2 control on the fate of human mesenchymal stromal cells ,Sacchetti, B;Fatica, A;Sorci, M;Sorrentino, A;Signore, M;Cerio, A;Felicetti, F;Feo, A;Pelosi, E;Caré, A;Pescarmona, E;Gordeladze, JO;Valtieri, M;, Regen Med Res 2017 ,PubMed ID 29206625 [GAPDH]
Shear stress induces noncanonical autophagy in intestinal epithelial monolayers ,Kim, SW;Ehrman, J;Ahn, MR;Kondo, J;Lopez, AAM;Oh, YS;Kim, XH;Crawley, SW;Goldenring, JR;Tyska, MJ;Rericha, EC;Lau, KS;, Mol. Biol. Cell 2017 ,PubMed ID 28855375 [GAPDH]
FMNL2 destabilises COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer ,Yang, SS;Li, XM;Yang, M;Ren, XL;Hu, JL;Zhu, XH;Wang, FF;Zeng, ZC;Li, JY;Cheng, ZQ;Liao, WT;Ding, YQ;Guan, J;Liang, L;, Br. J. Cancer 2017 ,PubMed ID 28817833 [GAPDH]
Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1(Y522S/WT) Mice ,Michelucci, A;De Marco, A;Guarnier, FA;Protasi, F;Boncompagni, S;, Oxid Med Cell Longev 2017 ,PubMed ID 29062463 [GAPDH]
Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway ,Shi, M;Zeng, X;Guo, F;Huang, R;Feng, Y;Ma, L;Zhou, L;Fu, P;, Molecules 2017 ,PubMed ID 28994737 [GAPDH]
Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa ,Fischer, MD;McClements, ME;Martinez-Fernandez de la Camara, C;Bellingrath, JS;Dauletbekov, D;Ramsden, SC;Hickey, DG;Barnard, AR;MacLaren, RE;, Mol. Ther. 2017 ,PubMed ID 28549772 [GAPDH]
Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia ,Michelucci, A;Paolini, C;Boncompagni, S;Canato, M;Reggiani, C;Protasi, F;, FASEB J. 2017 ,PubMed ID 28465322 [GAPDH]
miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions ,Ye, EA;Steinle, JJ;, Vision Res. 2017 ,PubMed ID 28433754 [GAPDH]
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo ,Bhattarai, N;McLinden, JH;Xiang, J;Mathahs, MM;Schmidt, WN;Kaufman, TM;Stapleton, JT;, PLoS Pathog 2017 ,PubMed ID 28235043 [GAPDH]
Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner ,Morelli, MB;Amantini, C;Nabissi, M;Cardinali, C;Santoni, M;Bernardini, G;Santoni, A;Santoni, G;, Oncotarget 2017 ,PubMed ID 27926485 [GAPDH]
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation ,Asperti, M;Stuemler, T;Poli, M;Gryzik, M;Lifshitz, L;Meyron-Holtz, EG;Vlodavsky, I;Arosio, P;, PLoS ONE 2016 ,PubMed ID 27711215 [GAPDH]
Alcohol Dehydrogenases and Acetaldehyde Dehydrogenases are Beneficial for Decidual Stromal Cells to Resist the Damage from Alcohol ,Li, Z;Li, M;Li, S;Fu, Y;Yang, Z;, Alcohol and Alcoholism 2016 ,PubMed ID 28182209 [GAPDH]
Renal Protective Effects of 17ß-Estradiol on Mice with Acute Aristolochic Acid Nephropathy ,Shi, M;Ma, L;Zhou, L;Fu, P;, Molecules 2016 ,PubMed ID 27763560 [GAPDH]
Data on the inhibition of RNase inhibitor activity by a monoclonal antibody as assessed by microfluidics-based RNA electrophoresis ,Wang, X;Teferedegne, B;Shatzkes, K;Tu, W;Murata, H;, Data Brief 2016 ,PubMed ID 27699193 [GAPDH]
Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition ,Pifer, PM;Farris, JC;Thomas, AL;Stoilov, P;Denvir, J;Smith, DM;Frisch, SM;, Mol. Biol. Cell 2016 ,PubMed ID 27251061 [APDH]
Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice ,Ma, X;Turnbull, PC;Crapper, EP;Wang, H;Drannik, A;Jiang, F;Xia, S;Turnbull, J;, Histochem. Cell Biol. Jan 2016 ,PubMed ID 26724814 [GAPDH]
TRAF3IP3, a novel autophagy-upregulated gene, is involved in MZ B lymphocyte development and survival ,Peng, S;Wang, K;Gu, Y;Chen, Y;Nan, X;Xing, J;Cui, Q;Chen, Y;Ge, Q;Zhao, H;, Clin. Exp. Immunol. May 2015 ,PubMed ID 26011558 [GAPDH]
Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis ,Yee, NS;Kazi, AA;Li, Q;Yang, Z;Berg, A;Yee, RK;, Biol Open Mar 2015 ,PubMed ID 25770184 [GAPDH]
Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3a Downregulation ,Zhang, D;Wang, Y;Shi, Z;Liu, J;Sun, P;Hou, X;Zhang, J;Zhao, S;Zhou, BP;Mi, J;, Cell Rep Mar 2015 ,PubMed ID 25732824 [GAPDH]
Toxicity of aflatoxin B1 towards the vitamin D receptor (VDR) ,Costanzo, P;Santini, A;Fattore, L;Novellino, E;Ritieni, A;, Food Chem. Toxicol. Dec 2014 ,PubMed ID 25483621 [GAPDH]
Novel APP K724M mutation causes Chinese EOFAD and increases amyloid-ß42/40 ratio ,Peng, XL;Hou, L;Xu, SH;Hua, Y;Zhou, SJ;Zhang, Y;, Neurobiology of Aging Jun 2014 ,PubMed ID 25018108 [GAPDH]
A novel protein is lower expressed in renal cell carcinoma ,Guan, R;Xu, Y;Lei, H;Gao, Z;Xin, Z;Guo, Y;, Int J Mol Sci May 2014 ,PubMed ID 24786097 [GAPDH]
Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion ,Yee, NS;Li, Q;Kazi, AA;Yang, Z;Berg, A;Yee, RK;, Cells May 2014 ,PubMed ID 24861976 [GAPDH]
Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Krüppel-like zinc-finger protein family and WT1 protein isoforms ,Francesca Florio, Elena Cesaro, Giorgia Montano, Paola Izzo, Colin Miles, and Paola Costanzo, Hum. Mol. Genet., Sep 2010; 19: 3544 – 3556 ,PubMed ID 20591825 [GAPDH]

LGR5 Mouse Monoclonal Antibody [Clone ID: OTI2A2]LGR5小鼠单克隆抗体[克隆ID：OTI2A2]

发表于由
Product Data
Clone Name OTI2A2
Applications FC, IF, IHC, IP, WB
Recommend Dilution WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100, IP 2ug/500ul
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 250-550 of human LGR5 (NP_003658) produced in HEK293T Cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 99.8 kDa
 Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

The use of this Antibodies has been cited in the following citations:
Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization ,Chen, HJ;Shuler, ML;, Methods Mol. Biol. 2019 ,PubMed ID 30542993 [LGR5]
Selection of a Malignant Subpopulation from a Colorectal Cancer Cell Line ,Lai, PL;Chen, TC;Feng, CY;Lin, H;Wu, N;Chen, Y;, bioRxiv 2019 [LGR5]
Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway ,Li, XG;Zhu, M;Chen, MX;Fan, HB;Fu, HL;Zhou, JY;, Toxicology Letters 2019 ,PubMed ID 30690062 [LGR5]
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri ,Liu, S;Zheng, Z;Ji, S;Liu, T;Hou, Y;Li, S;Li, G;, Fish Shellfish Immunol. 2018 ,PubMed ID 29908321 [LGR5]
NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells ,Ma, X;Wang, B;Wang, X;Luo, Y;Fan, W;, PLoS ONE 2018 ,PubMed ID 29689047 [LGR5]
Liver damage, proliferation, and progenitor cell markers in experimental necrotizing enterocolitis ,Miyake, H;Li, B;Lee, C;Koike, Y;Chen, Y;Seo, S;Pierro, A;, J. Pediatr. Surg. 2018 ,PubMed ID 29502797 [LGR5]
Identification of PMN-released Mutagenic Factors in a Co-culture Model for Colitis-associated Cancer ,Granofszky, N;Lang, M;Khare, V;Schmid, G;Scharl, T;Ferk, F;Jimenez, K;Knasmüller, S;Campregher, C;Gasche, C;, Carcinogenesis 2017 ,PubMed ID 29106440 [LGR5]
Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases ,Yang, Q;Bavi, P;Wang, JY;Roehrl, MH;, J Proteomics 2017 ,PubMed ID 28669815 [LGR5]
LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1 ,Wang, B;Chen, Q;Cao, Y;Ma, X;Yin, C;Jia, Y;Zang, A;Fan, W;, PLoS ONE 2016 ,PubMed ID 28033430 [LGR5]
Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase ,Patel, NJ;Sharon, C;Baranwal, S;Boothello, RS;Desai, UR;Patel, BB;, Oncotarget 2016 ,PubMed ID 27705927 [LGR5]
A recellularized human colon model identifies cancer driver genes ,Chen, HJ;Wei, Z;Sun, J;Bhattacharya, A;Savage, DJ;Serda, R;Mackeyev, Y;Curley, SA;Bu, P;Wang, L;Chen, S;Cohen-Gould, L;Huang, E;Shen, X;Lipkin, SM;Copeland, NG;Jenkins, NA;Shuler, ML;, Nat. Biotechnol. 2016 ,PubMed ID 27398792 [LGR5]
Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer ,Osawa, H;Takahashi, H;Nishimura, J;Ohta, K;Haraguchi, N;Hata, T;Yamamoto, H;Mizushima, T;Takemasa, I;Doki, Y;Mori, M;, Br. J. Cancer May 2016 ,PubMed ID 27140312 [LGR5]
LGR5 activates non-canonical Wnt-signaling and inhibits aldosterone production in the human adrenal ,Shaikh, LH;Zhou, J;Teo, AE;Garg, S;Neogi, SG;Figg, N;Yeo, GS;Yu, H;Maguire, JJ;Zhao, W;Bennett, MR;Azizan, EA;Davenport, AP;McKenzie, G;Brown, MJ;, J. Clin. Endocrinol. Metab. Apr 2015 ,PubMed ID 25915569 [LGR5]
CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression ,Hsu, HC;Liu, YS;Tseng, KC;Yang, TS;Yeh, CY;You, JF;Hung, HY;Chen, SJ;Chen, HC;, J. Cancer Res. Clin. Oncol. July 2014 ,PubMed ID 25060070 [LGR5]
LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/ß-catenin signaling pathway in colorectal cancer cells ,Hsu, HC;Liu, YS;Tseng, KC;Tan, BC;Chen, SJ;Chen, HC;, Cell. Signal. July 2014 ,PubMed ID 25025569 [LGR5]
Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro ,Wang, J;Guo, X;Lui, M;Chu, PJ;Yoo, J;Chang, M;Yen, Y;, PLoS ONE, Jan 2014. ,PubMed ID 24465489 [LGR5]
Postnatal epithelium and mesenchyme stem/progenitor cells in bioengineered amelogenesis and dentinogenesis ,Jiang, N;Zhou, J;Chen, M;Schiff, MD;Lee, CH;Kong, K;Embree, MC;Zhou, Y;Mao, JJ;, Biomaterials Dec 2013. ,PubMed ID 24345734 [Lgr5]
Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers ,Chen Wu, Yuanyuan Xie, Feng Gao, Yanan Wang, Yawei Guo, Huanna Tian, Yanshuang Li, Wufang Fan, Gene. 2013 Aug 1;525(1):18-25 ,PubMed ID 23664892 [LGR5]
PKH26 staining defines distinct subsets of normal human colon epithelial cells at different maturation stages ,Pastò A, Marchesi M, Diamantini A, Frasson C, Curtarello M, Lago C, Pilotto G, Parenti AR, Esposito G, Agostini M, Nitti D, Amadori A, PLoS One. 2012;7(8):e43379 ,PubMed ID 22927961 [LGR5]