上海金畔代理Lumiprobe品牌活性荧光染料产品

发表于2024年9月18日由上海金畔生物

Lumiprobe Corporation是美国一家高品质生物技术公司，专业提供分子生物学研究用的活性荧光染料。从2006年开始，公司生产并销售生命科学研究和诊断学应用的优质化学药品。产品主要有：活性染料(Reactive Dye)和SYBR Green I 染料，用于寡核苷酸合成的亚磷酰胺，点击化学用染料和其它试剂。产品主要应用：点击化学(Click Chemistry)、蛋白质组学研究中的双向荧光差异凝胶电泳(2D DIGE)和实时荧光定量PCR(Realtime PCR)。其中，氨基类染料是包含自由氨基的活性染料，染料可与活化羧酸衍生物和其他亲电子的试剂结合。比如：氨基与EDC-活化的羧基结合。

上海金畔生物科技有限公司作为Lumiprobe中国正规签约授权代理商，Lumiprobe上海金畔生物官网：http://lumiprobe.jinpanbio.com/。可提供Lumiprobe产品，产品货期10个工作日左右，满足您的各种科研实验需求。Lumiprobe产品包括：羧酸类染料、羰基类染料，标记分子氨基活性染料，标记分子巯基活性染料，动物活体成像用染料，蛋白质、多肽、核酸等生物分子标记染料、点击化学等。渠道正规，质量保证，价格优惠。

炔烃 Dye alkynes

1-Ethynyl pyrene
3-Ethynyl perylene
BDP FL alkyne
FAM alkyne, 5-isomer
FAM alkyne, 6-isomer
TAMRA alkyne, 5-isomer
BDP TMR alkyne
Cyanine3 alkyne
Cyanine5 alkyne
Cyanine5.5 alkyne
Cyanine7 alkyne
Cyanine7.5 alkyne
Sulfo-Cyanine3 alkyne
Sulfo-Cyanine5 alkyne

叠氮化物 Dye azides

Pyrene azide 1/ Pyrene azide 2
PEP azide
Perylene azide
BDP FL azide
Coumarin 343 azide
FAM azide, 5-isomer
FAM azide, 6-isomer
TAMRA azide, 5- isomer
BDP TMR azide
Cyanine3 azide
Cyanine3.5 azide
Cyanine5 azide
Cyanine5.5 azide
Cyanine7 azide
Cyanine7.5 azide
Sulfo-Cyanine3 azide
Sulfo-Cyanine5 azide
Sulfo-Cyanine7 azide

N-羟基琥珀酰亚胺脂Dye NHS esters

Pyrenebutyric acid NHS ester
ROX NHS ester, pure 6- isomer
BDP FL NHS ester
FAM NHS ester
Cyanine3 NHS ester
Cyanine3.5 NHS ester
Cyanine5 NHS ester
Cyanine5.5 NHS ester
Cyanine7 NHS ester
Cyanine7.5 NHS ester
Sulfo-Cyanine3 NHS ester
Sulfo-Cyanine5 NHS ester
sulfo-Cyanine5 bis-NHS ester
Sulfo-Cyanine7 NHS ester

马来酰亚胺 Dye maleimides

Pyrene maleimide
BDP FL maleimide
Cyanine3 maleimide
Cyanine5 maleimide
Cyanine5.5 maleimide
Cyanine7 maleimide
Cyanine7.5 maleimide
Sulfo-Cyanine3 maleimide
Sulfo-Cyanine5 maleimide

伯胺 Primary amine

BDP FL amine
Cyanine3 amine
Cyanine5 amine
Cyanine5.5 amine
Cyanine7 amine
Cyanine7.5 amine
Sulfo-Cyanine5 amine
Sulfo-Cyanine7 amine

酰肼 Dye hydrazides

Pyrene hydrazide
BDP FL hydrazide
Cyanine3 hydrazide
Cyanine5 Boc-hydrazide
Cyanine5 hydrazide
Cyanine5.5 hydrazide
Cyanine7 hydrazide
Cyanine7.5 hydrazide

马来酰亚胺 Dye maleimides

BDP FL maleimide
Cyanine3 maleimide
Cyanine5 maleimide
Cyanine5.5 maleimide
Cyanine7 maleimide
Cyanine7.5 maleimide
Sulfo-Cyanine3 maleimide
Sulfo-Cyanine5 maleimide

羧酸 Carboxylic acids

Pyrenebutyric acid
BDP FL carboxylic acid
Cyanine3 carboxylic acid
Cyanine3.5 carboxylic acid
Cyanine5 carboxylic acid
Cyanine5.5 carboxylic acid
Cyanine7 carboxylic acid
Cyanine7.5 carboxylic acid
Sulfo-Cyanine3 carboxylic acid
Sulfo-Cyanine5 carboxylic acid
Sulfo-Cyanine7 carboxylic acid

点击化学试剂

非荧光炔烃 Non-fluorescent alkynes

Pentynoic acid STP ester
Biotin alkyne

非荧光叠氮化物 Non-fluorescent azides

Azidobutyric acid NHS ester
Biotin azide

寡核苷酸分析

亚磷酰胺 Phosphoramidites

FAM Phosphoramidite, 6-Isomer
Alkyne Amidite, hydroxyprolinol
Alkyne Phosphoramidite, 5′-terminal
DMS(O)MT aminolink C6
Long trebler phosphoramidite
Pyrene phosphoramidite dU

PCR/qPCR PCR/qPCR

ROX reference dye for qPCR
SYBR Green I Gel Staining Solution, 10000x
SYBR Green I for Real Time PCR, 100x

CPG固相修饰 CPG solid supports

Alkyne CPG modifier 500
TFA-Amino modifier CPG 500

三磷酸酯修饰 Modified triphosphates

Amino-11-ddUTP
Amino-11-dUTP

其它试剂

蛋白质组学试剂 Proteomic reagents

3Dye™ 2D DIGE Kits
Cyanine2 NHS ester minimal dye
Cyanine3 NHS ester minimal dye
Cyanine5 NHS ester minimal dye

辅助试剂 Auxiliary reagents

Ascorbic acid
Copper(II)-TBTA complex, 10 mM in 55% aq. DMSO
DMF (dimethylformamide), labeling grade

Lumiprobe Perylene azide荧光染料

发表于2024年9月16日由上海金畔生物

Lumiprobe Perylene azide荧光染料

Perylene是一种高亮度的且对公极其稳定的多环芳烃（PAH）类荧光染料，其量子产率接近理想化。
因其很短的荧光期，这种探针没有激发态。
因其较低的溶解度和很少量的活性衍生物，Perylene标记生物分子通常比较困难且不太容易实现。然而，通过点击化学使用这种perylene azide来进行标记就变得和其他染料一样非常容易。使用这种多环芳烃染料标记多肽、DNA、蛋白等从未如此轻松。
为了提高其亲水性和标记成功率，这种PAH azide包含亲水三甘醇链。

Perylene is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with quantum yield approaching quantitative.

Due to low life time of fluorescence, this probe does not form excimers.

Perylene labeling of biomolecules is used to be difficult and tedious because of low solubility of perylene, and low availability of activated derivatives. However, labeling via Click Chemistry with this perylene azide is nearly as easy, as with other dyes. Labeling peptide, DNA, protein with this polyaromatic hydrocarbon has never been so simple yet.

To increase hydrophilicity, and facilitate labeling, this PAH azide contains hydrophilic triethyleneglycol linker.

订购货号	产品名称及规格
A5530	Perylene azide, 1 mg
B5530	Perylene azide, 5 mg
C5530	Perylene azide, 10 mg
D5530	Perylene azide, 25 mg
E5530	Perylene azide, 50 mg

General properties

Appearance:	orange-yellow solid
Molecular weight:	452.50
Molecular formula:	C27H24N4O3
Solubility:	good in dichloromethane and chloroform, moderate in DMSO, DMF, and acetonitrile
Quality control:	NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
MSDS:	Download

Lumiprobe 23420 BDP TR NHS ester

发表于2023年10月14日由上海金畔生物

Lumiprobe 23420 BDP TR NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授权证书）

欢迎访问Lumiprobe官网或者咨询我们获取更多产品信息。

货期：仅需要5-7工作日，不需要像其他家攒单导致货期3-4周。

BDP TR is a bright and photostable borondipyrromethene dye, which is especially suitable for microscopy applications. The dye has a long excited state lifetime, and is therefore is useful for fluorescence polarization assays. Its large two-photon cross section makes this dye useful for two-photon spectroscopy.

This NHS ester is an amine-reactive form of the dye.

Lumiprobe 23420 BDP TR NHS ester

Cat. #	Quantity	Lead time
13420	1 mg	in stock
23420	5 mg	in stock
43420	25 mg	in stock
53420	50 mg	in stock
63420	100 mg	in stock

BDP TR NHS ester structure

Absorption and emission spectra of BODIPY TR

General properties

Appearance:	dark blue-black crystals
Mass spec M+ increment:	406.1
Molecular weight:	521.30
Molecular formula:	C₂₅H₁₈BF₂N₃O₅S
IUPAC name:	Methyl {p-[4,4-difluoro-5-(2-thienyl)-3a,4a-diaza-4-bora-s-indacen-3-yl]phenoxy}acetate
Quality control:	HPLC-MS (95%), UV-Vis
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	589
ε, L⋅mol⁻¹⋅cm⁻¹:	69000
Emission maximum, nm:	616
Fluorescence quantum yield:	0.9
CF₂₆₀:	0.15
CF₂₈₀:	0.19

Lumiprobe Bodipy（BDP）活性染料产品列表

BDP 558/568 NHS ester

BDP 581/591 NHS ester

BDP 630/650 X NHS ester

BDP FL NHS ester

BDP R6G NHS ester

BDP TMR NHS ester

BDP TR NHS ester

BDP 558/568 azide

BDP 581/591 azide

BDP 630/650 azide

BDP FL azide

BDP R6G azide

BDP TMR azide

BDP TR azide

BDP 558/568 alkyne

BDP 581/591 alkyne

BDP 630/650 alkyne

BDP FL alkyne

BDP R6G alkyne

BDP TMR alkyne

BDP TR alkyne

BDP 581/591 maleimide

BDP 630/650 maleimide

BDP FL maleimide

BDP R6G maleimide

BDP TMR maleimide

BDP TR maleimide

BDP 581/591 hydrazide

BDP 630/650 hydrazide

BDP FL hydrazide

BDP TR hydrazide

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 581/591 tetrazine

BDP 630/650 tetrazine

BDP FL tetrazine

BDP TR tetrazine

BDP 581/591 DBCO

BDP FL DBCO

BDP R6G DBCO

BDP TR methyl ester, 5 mM in DMSO

Lumiprobe 26420 BDP 581/591 NHS ester

发表于2023年10月14日由上海金畔生物

Lumiprobe 26420 BDP 581/591 NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授权证书）

欢迎访问Lumiprobe官网或者咨询我们获取更多产品信息。

货期：仅需要5-7工作日，不需要像其他家攒单导致货期3-4周。

Lumiprobe 26420 BDP 581/591 NHS ester

BDP 581/591 is a borondipyrromethene dye that has relatively long fluorescence lifetime and two photon excitation cross section. It is useful for fluorescence polarization assays. Due to the presence of a diene system, it can react with reactive oxygen species (ROS) with a change of fluorescence.

This is the NHS ester derivative for the conjugation with primary and secondary amine groups of proteins, peptides, and other molecules.

Cat. #	Quantity	Lead time
16420	1 mg	in stock
26420	5 mg	in stock
46420	25 mg	in stock
56420	50 mg	in stock
66420	100 mg	in stock

BDP 581/591 NHS ester

Absorption and emission spectra of BDP 581/591

General properties

Appearance:	dark colored solid
Mass spec M+ increment:	374.1
Molecular weight:	489.28
Molecular formula:	C₂₆H₂₂N₃BF₂O₄
Solubility:	good in DMF, DMSO, DCM
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	585
Emission maximum, nm:	594
CF₂₆₀:	0.06
CF₂₈₀:	0.04

Product citations

Tabe, H.; Sukenobe, K.; Kondo, T.; Sakurai, A.; Maruo, M.; Shimauchi, A.; Hirano, M.; Uno, S.-N.; Kamiya, M.; Urano, Y.; Matsushita, M.; Fujiyoshi, S. Cryogenic Fluorescence Localization Microscopy of Spectrally Selected Individual FRET Pairs in a Water Matrix. The Journal of Physical Chemistry B, 2018, 122(27), 6906–6911. doi: 10.1021/acs.jpcb.8b03977

Lumiprobe Bodipy（BDP）活性染料产品列表

发表于2023年10月14日由上海金畔生物

Lumiprobe Bodipy（BDP）活性染料产品列表

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授权证书）

欢迎访问Lumiprobe官网或者咨询我们获取更多产品信息。

货期：仅需要5-7工作日，不需要像其他家攒单导致货期3-4周。

Lumiprobe Bodipy（BDP）活性染料产品列表

BDP 558/568 NHS ester

BDP 581/591 NHS ester

BDP 630/650 X NHS ester

BDP FL NHS ester

BDP R6G NHS ester

BDP TMR NHS ester

BDP TR NHS ester

BDP 558/568 azide

BDP 581/591 azide

BDP 630/650 azide

BDP FL azide

BDP R6G azide

BDP TMR azide

BDP TR azide

BDP 558/568 alkyne

BDP 581/591 alkyne

BDP 630/650 alkyne

BDP FL alkyne

BDP R6G alkyne

BDP TMR alkyne

BDP TR alkyne

BDP 581/591 maleimide

BDP 630/650 maleimide

BDP FL maleimide

BDP R6G maleimide

BDP TMR maleimide

BDP TR maleimide

BDP 581/591 hydrazide

BDP 630/650 hydrazide

BDP FL hydrazide

BDP TR hydrazide

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 581/591 tetrazine

BDP 630/650 tetrazine

BDP FL tetrazine

BDP TR tetrazine

BDP 581/591 DBCO

BDP FL DBCO

BDP R6G DBCO

BDP TR methyl ester, 5 mM in DMSO

Lumiprobe BDP FL NHS ester

发表于2023年10月14日由上海金畔生物

Lumiprobe BDP FL NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授权证书）

货期：仅需要5-7工作日，不需要像其他家攒单导致货期3-4周。

Lumiprobe BDP FL NHS ester

Cat. #	Quantity	Lead time
11420	1 mg	in stock
			21420	5 mg	in stock
41420	25 mg	in stock
			51420	50 mg	in stock
61420	100 mg	in stock

BDP FL NHS ester is an advanced dye for 488 nm channel, a replacement for fluorescein, a molecule identical to BODIPY FL® NHS ester. An amino-reactive dye for the labeling of proteins and peptides.

While the absorbance and emission spectra of this molecule stay within FAM excitation and emission channels, this dye provides much better photostability, and outstanding brightness. The fluorescence spectrum of BODIPY-FL is narrower than that of FAM. This provides a better brightness for monochromator based instruments, when emission wavelength can be tuned to dye maximum.

The dye is neutral, possesses low molecular weight, and retains high quantum yield in conjugates.

The dye is a good replacement for fluorescein (FAM), BODIPY-FL, Alexa Fluor 488, DyLight 488, Cy2, and other 488 nm dyes.

BDP FL NHS ester

Photo of BDP FL solution

Structure of BODIPY FL NHS ester

Absorption and emission spectra of BDP FL

General properties

Appearance:	orange solid
Mass spec M+ increment:	274.1
Molecular weight:	389.16
CAS number:	146616-66-2
Molecular formula:	C₁₈H₁₈BF₂N₃O₄
Solubility:	Good in organic solvents (DMF, DMSO, dichlromethane), limited in water
Quality control:	NMR ¹H, HPLC-MS (95+%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	503
ε, L⋅mol⁻¹⋅cm⁻¹:	80000
Emission maximum, nm:	509
Fluorescence quantum yield:	0.97
CF₂₆₀:	0.015
CF₂₈₀:	0.027

Product citations

Poreba, M.; Rut, W.; Vizovisek, M.; Groborz, K.; Kasperkiewicz, P.; Finlay, D.; Vuori, K.; Turk, D.; Turk, B.; Salvesen, G.; Drag, M.Selective imaging of human cathepsin L in breast cancer by fluorescent activity-based probes. Chemical Science, 2018, 9(8), 2113–2129. doi: 10.1039/C7SC04303A
Grube, L.; Dellen, R.; Kruse, F.; Schwender, H.; Stuehler, K.; Poschmann, G. Mining the secretome of C2C12 muscle cells: Data dependent experimental approach to analyze protein secretion using label-free quantification and peptide based analysis. Journal of Proteome Research, 2018, 17(2), 879–890. doi: 10.1021/acs.jproteome.7b00684
Wang, C.; Niederstrasser, H.; Douglas, P.M.; Lin, R.; Jaramillo, J.; Li, Y.; Olswald, N.W.; Zhou, A.; McMillan, E.A.; Mendiratta, S.; Wang, Z.; Zhao, T.; Lin, Z.; Luo, M.; Huang, G.; Brekken, R.A.; Posner, B.A.; MacMillan, J.B.; Gao, J.; White, M.A. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature Communications, 2017, 8, 2270. doi: 10.1038/s41467-017-02332-3
Gaspar, I.; Wippich, F.; Ephrussi, A. Enzymatic production of single molecule FISH and RNA capture probes. RNA, 2017, 23(10), 1582–1591. doi: 10.1261/rna.061184.117

Bodipy(BDP)氟硼荧光活性染料发展历史

Bodipy二吡咯类荧光染料相对比于荧光素、罗丹明或者菁染料有着较高的选择性、高灵敏度、高荧光量子产率、高摩尔消光系数、良好的光学稳定性和对PH不敏感的优点被广泛应用于生物标记、荧光探针及生物成像，西安瑞禧生物科技有限公司可以提供种类丰富的Bodipy荧光染料，荧光波长可定制从550-800之间，末端可以修饰各种活性基团。

Bodipy类荧光染料具有良好的稳定性、优良的光学性能，主要表现在以下几个方面：

1：BODIPY的光谱峰宽比较窄，在光学领域和生物学领域进行分析检测时，光谱峰宽较窄，检测灵敏度较高，并且减少了待测样品的用量。测得的结果中，荧光光谱上会出现更为明显的荧光吸收和发射的变化，这样更精确地测得了样品的含量。

2：在整个BODIPY分子中，并不存在负电荷。因而在溶液中，溶液中的离子无法与缺少电荷的BODIPY分子发生静电作用，这样非常有效的避免了测定时静电作用对测量结果的干扰，使测定过程更加稳定，测得结果更加精准。

3：BODIPY类荧光染料的光稳定性能非常优越，当它被激发到达激发态时，不会因为很长时间的激发而在分析测定过程中发生激发态的分解或其他变化，这样测得的荧光光谱更加准确可信。

4：BODIPY染料，其荧光量子产率甚至接近1.0。一般普通的染料在水溶液中其荧光量子产率会变低，有的甚至被猝灭。对于BODIPY分子来说，在水溶液中其荧光量子产率虽然有所下降，但它仍然能保持较高的荧光量子产率。

5：由BODIPY的母体结构可知，他的母体结构上的取代基一般不会出现氨基或羧基这类对酸碱敏感的活性基团。因此外界的酸碱度对其影响会大幅度减小，因此BODIPY染料不会轻易变质。

6：BODIPY类荧光染料对光的感应度很高，并且它还有高的摩尔消光系数，有些经过修饰后的BODIPY染料在水溶液中的溶解度也较高，再加上它在水中不易被猝灭这一优异的性能，使得BODIPY在光学、生物学、分析学领域有着极其广泛的应用。

西安瑞禧生物科技有限公司可以提供激发和发射波长从500nm-800nm的活性染料（包括800nm左右的近红外）并且可以修饰NHS、MAL、NH2、COOH、N3、SH等不同活性基团。

常规的Bodipy荧光染料都是激发发射波长都是在500-650nm之间的，包括国外的商家也只能提供500-650nm波长的荧光染料，瑞禧生物不仅可以提供波长在500-600nm之间的波长还可以提供650-800nm之间的近红外波段的BDP

500-800之间的波长可以选择：
Bodipy carboxylic acid（羧基COOH）
Bodipy NHS ester（活化脂NHS）
Bodipy amine （NH2氨基）
Bodipy maleimide （MAL马来酰亚胺）
Bodipy azide （N3叠氮）
Bodipy alkyne （ALK炔烃）
Bodipy hydrazide （HZ酰基）
Bodipy Thiol （HS巯基）

产品列表：
BODIPY™ FL NHS Ester (Succinimidyl Ester)
BODIPY™ FL Sulfonated Succinimidyl Ester
BODIPY™ FL-X NHS Ester (Succinimidyl Ester)
BODIPY™ TMR-X NHS Ester (Succinimidyl Ester)
BODIPY™ 530/550 NHS Ester (Succinimidyl Ester)
BODIPY™ R6G NHS Ester (Succinimidyl Ester)
BODIPY™ 581/591 NHS Ester (Succinimidyl Ester)
BODIPY™ 576/589 NHS Ester (Succinimidyl Ester)
BODIPY™ 650/665-X NHS Ester (Succinimidyl Ester)
BODIPY™ 493/503 NHS Ester (Succinimidyl Ester)
BODIPY™ 558/568 NHS Ester (Succinimidyl Ester)
BODIPY™ TR-X NHS Ester (Succinimidyl Ester)
BODIPY™ 630/650-X NHS Ester (Succinimidyl Ester)
BODIPY™ FL maleimide
BODIPY™ FL azide
BODIPY™ FL alkyne
BODIPY™ FL hydrazide
BODIPY™ FL amine
BODIPY™ FL Carboxylic acid
BODIPY™ TR ceramide
BODIPY™ FL STP ester
BODIPY™ FL C12-sphingomyelin
BODIPY™ R6G NHS Ester
BODIPY™ 558/568 phalloidin
BODIPY™ FL hydrazide
BODIPY™ TMR-X NHS Ester
BODIPY™ FL L-cystine
BODIPY™ FL Carboxylic acid
BODIPY™ FL Carboxylic acid
BODIPY™ FL Carboxylic acid

BODIPY®493/503 NHS ester
BODIPY®493/503 Carboxylic acid
BODIPY®493/503 amine
BODIPY®493/503 maleimide
BODIPY®493/503 azide
BODIPY®493/503 alkyne

BODIPY®558/568 NHS ester
BODIPY®558/568 Carboxylic acid
BODIPY®558/568 amine
BODIPY®558/568 maleimide
BODIPY®558/568 azide
BODIPY®558/568 alkyne

BODIPY®650/665 NHS ester
BODIPY®650/665 Carboxylic acid
BODIPY®650/665 amine
BODIPY®650/665 maleimide
BODIPY®650/665 azide
BODIPY®650/665 alkyne

BODIPY FL NHS Ester
BODIPY TMR NHS Ester
BODIPY TR NHS Ester
BODIPY FL amine
BODIPY TMR amine
BODIPY TR amine

以下染料的激发波长是685nm 发射波长是720nm
Azo-Bodipy-685 (ABDP685)
Azo-Bodipy 685 carboxylic acid
Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 carboxylic acid
Azo-Bodipy 685 NHS ester
Sulfo-Azo-Bodipy 685 NHS ester
Azo-Bodipy 685 amine
Sulfo-Azo-Bodipy 685 amine
PEG-Azo-Bodipy 685 NHS ester
PEG- Azo-Bodipy 685 amine
Azo-Bodipy 685 alkyne
Sulfo-Azo-Bodipy 685 alkyne
Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 azide
Azo-Bodipy 685 maleimide
Sulfo-Azo-Bodipy 685 maleimide
Azo-Bodipy 685 pH6.5

我们还接受激发波长和发射波长在500nm-800nm之间的BDP活性荧光染料的定制产品。
上面所述染料可以连接：COOH, NH₂, NHS, MAL, N₃, ALK, hydrazide, SH

其他波长的BDP活性染料的产品列表：
产品列表：
BDP 558/568 NHS ester
BDP 581/591 NHS ester
BDP 630/650 X NHS ester
BDP FL NHS ester
BDP R6G NHS ester
BDP TMR NHS ester
BDP TR NHS ester

BDP 581/591 azide
BDP 630/650 azide
BDP FL azide
BDP R6G azide
BDP TMR azide
BDP TR azide

BDP 558/568 alkyne
BDP 581/591 alkyne
BDP 630/650 alkyne
BDP FL alkyne
BDP R6G alkyne
BDP TMR alkyne
BDP TR alkyne

BDP 581/591 maleimide
BDP 630/650 maleimide
BDP FL maleimide
BDP R6G maleimide
BDP TMR maleimide
BDP TR maleimide

BDP 581/591 hydrazide
BDP 630/650 hydrazide
BDP FL hydrazide
BDP TR hydrazide

BDP 558/568 carboxylic acid
BDP 581/591 carboxylic acid
BDP 630/650 carboxylic acid
BDP FL carboxylic acid
BDP R6G carboxylic acid
BDP TMR carboxylic acid
BDP TR carboxylic acid

BDP 581/591 amine
BDP 630/650 amine
BDP FL amine
BDP R6G amine
BDP TMR amine
BDP TR amine

BDP 581/591 tetrazine
BDP 630/650 tetrazine
BDP FL tetrazine
BDP TR tetrazine

BODIPY母体结构最初是由德国化学家Treibs, A.和kreuzer, F. H.在1968年合成的，他们合成的BODIPY 类荧光染料 [40] 。另外，他们还合成了BODIPY染料的母体结构。在BODIPY母体结构中，Treibs, A.和kreuzer, F. H.在R1-R7中用不同基团取代得到不同的衍生产物。人们根据Treibs, A.和kreuzer, F. H.的前期探索，对BODIPY类染料做出了多种结构修饰，这大大丰富了BODIPY的种类，使其迅猛发展。

Lumiprobe Cy5.5羧酸 Cyanine5.5 carboxylic acid

发表于2023年9月23日由上海金畔生物

Lumiprobe Cy5.5羧酸 Cyanine5.5 carboxylic acid

英文名：Cyanine5.5 carboxylic acid
级别：NMR 1H (95%) and 13C， TLC
分子式：C40H43ClN2O2
分子量：619.23
品牌：lumiprobe
CAS：1144107-80-1， 1256349-47-9
外观：dark blue powder

订购货号	产品名称及规格
17090	Cyanine5.5 carboxylic acid, 1 mg
27090	Cyanine5.5 carboxylic acid, 5 mg
47090	Cyanine5.5 carboxylic acid, 25 mg
57090	Cyanine5.5 carboxylic acid, 50 mg
67090	Cyanine5.5 carboxylic acid, 100 mg

Cyanine5.5 dye，游离酸形式，非活性染料。该染料对大多数应用可以理解为非活性。它可以用作对照或参考样本，和对仪器进行校准。
预活化的NHS ester染料可以用于氨基基团的标记。Cy® is a trademark of GE Healthcare.General properties

Appearance:	dark blue powder
Molecular weight:	619.23
Molecular formula:	C₄₀H₄₃ClN₂O₂
CAS number:	1144107-80-1, 1256349-47-9
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR 1H (95%) and 13C, TLC
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	673
Extinction coefficient at excitation maximum, Lmol-1cm-1:	209000
Emission maximum, nm:	707
Fluorescence quantum yield:	0.2

Product citations

Camerino, M.A.; Liu, M.; Moriya, S.; Kitahashi, T.; Mahgoub, A.; Mountford, S.J.; Chalmers, D.K.; Soga, T.; Parhar, I.S.; Thompson, P.E. Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity. Journal of Peptide Science, 2016, 22(6), 406–414. doi: 10.1002/psc.2883

Zhao, Y.; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bjørkøy, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature Communications, 2016, 7, 11221. doi: 10.1038/ncomms11221

Kwok, S.J.J.; Choi, M.; Bhayana, B.; Zhang, X.; Ran, C.; Yun, S.-H. Two-photon excited photoconversion of cyanine-based dyes.Scientific Reports, 2016, 6, 23866. doi: 10.1038/srep23866

Wang, X.; Wang, C.; Zhang, Q.; Cheng, Y. Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery. Chemical Communications, 2016, 52, 978–981. doi: 10.1039/c5cc08391e
Kim, K.S.; Park, W.; Hu, J.; Bae, Y.H.; Na, K. A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle.Biomaterials, 2014, 35(1), 337-343. doi: 10.1016/j.biomaterials.2013.10.004

Lee, B.-S.; Amano, T.; Wang, H.Q.; Pantoja, J.L.; Yoon, C.W.; Hanson, C.J.; Amatya, R.; Yen, A.; Black, K.L.; Yu, J.S. Reactive Oxygen Species Responsive Nanoprodrug to Treat Intracranial Glioblastoma. ACS Nano, 2013, 7(4), 3061-3077. doi:10.1021/nn400347j

Cy5.5马来酰亚胺–标记分子巯基的活性染料

发表于2023年9月23日由上海金畔生物

Cy5.5马来酰亚胺–标记分子巯基的活性染料

Cy5.5马来酰亚胺 Cyanine5.5 maleimide

Cy5.5马来酰亚胺是巯基活性染料，可以标记蛋白的巯基。近红外Cy5.5可用于小动物成像。
Cy5.5可以代替Alexa Fluor 680，DyLight 680

分子结构：

一般性质：
外观：深蓝色粉末
分子量：741.36
分子式：C46H49ClN4O3
溶解性：溶于有机溶剂（DMSO,DMF,二氯甲烷），略溶于水
质控：NMR 1H（95%）和13C,TLC,功能测试光谱性质：
最大激发波长：673nm
最大激发波长下的消光系数：209000Lmol^-1cm^-1
最大发射波长：707nm
荧光量子产率：0.2

Cy5马来酰亚胺 Cyanine5.5 maleimide

Cy5马来酰亚胺是标记多肽和蛋白巯基的活性染料，此染料可与多种设备兼容，比如显微镜，成像仪和荧光读数仪。分子结构：

一般性质：
外观：深蓝色粉末
分子量：641.24
分子式：C38H45ClN4O3
溶解性：溶于有机溶剂（DMF,DMSO,二氯甲烷），不溶于水
质控：NMR 1H（95%）和13C,TLC,功能测试光谱特性：
最大激发波长：646nm
在最大激发波长下的消光系数：250000Lmol^-1cm^-1
最大激发波长：662nm
荧光量子产率：0.2

Cy3马来酰胺 Cyanine3 maleimide

巯基活性Cy3染料，可以将Cy3荧光团结合到蛋白和多肽的巯基上。分子结构：

一般性质：
外观：红色粉末
分子量：615.2
分子式：C36H43ClN4O3
溶解性：溶于有机溶剂（DMF，DMSO，二氯甲烷），不溶于水
质控：NMR 1H（95%）和13C,TLC，功能测试光谱性质：
最大激发波长：555nm
在最大激发波长下的消光系数：150000Lmol^-1cm^-1
最大发射波长:570nm
荧光量子产率：0.31

Cy7马来酰亚胺 Cyanine7 maleimide

近红外，巯基活性Cy7染料。此试剂可将近红外的Cy7染料连接到蛋白的巯基上，标记的蛋白可以用于近红外生物成像。分子结构：

一般性质：
外观：绿色粉末
分子量：707.34
分子式：C43H51ClN4O3
溶解性：易溶于DMF,DMSO，二氯甲烷，不易溶于水
质控：NMR 1H(95%)13C,TLC,功能测试光谱性质：
最大激发波长：750nm
在最大激发波长下的消光系数：199000Lmol^-1cm^-1
最大发射波长：773nm
荧光量子产率：0.3

Cy7.5马来酰亚胺 Cyanine7.5 maleimide

巯基活性，近红外染料Cy7.5用于标记生物分子的巯基。
多数蛋白含有巯基，可由马来酰亚胺进行选择性标记。使用此试剂，这些蛋白可以转化为近红外荧光素结合物。标记后的复合物可以用于活体动物成像，研究组织和器官中蛋白的分配。分子结构：

一般性质：
外观：绿色粉末
分子量：807.46
分子式：C51H55ClN4O3
溶解性：易溶于DMF,DMSO，二氯甲烷，不易溶于水
质控：NMR 1H(95%)13C,TLC,功能测试
保存条件：保存：-20℃，避光保存24个月。运输：常温下最多3周，避光，干燥。光谱性质：
最大激发波长：788nm
在最大激发波长下的消光系数：223000Lmol^-1cm^-1
最大发射波长：808nm

Cy5.5马来酰亚胺–标记分子巯基的活性染料

Lumiprobe cy7.5马来酰亚胺|Cyanine7.5 maleimide

发表于2023年9月23日由上海金畔生物

Lumiprobe cy7.5马来酰亚胺|Cyanine7.5 maleimide

英文名：Cyanine7.5 maleimide
级别：NMR 1H (95%) and 13C， TLC， functional testing
分子式：C51H55ClN4O3
分子量：807.46
品牌：lumiprobe
外观：green powder

订购货号	产品名称及规格
16080	Cyanine7.5 maleimide, 1 mg
26080	Cyanine7.5 maleimide, 5 mg
46080	Cyanine7.5 maleimide, 25 mg
56080	Cyanine7.5 maleimide, 50 mg
66080	Cyanine7.5 maleimide, 100 mg

硫醇活性染料、近红外Cyanine7.5，用于标记蛋白的巯基基团，是Cy7.5® maleimide的类似物。
大多数蛋白含有巯基基团，可以选择性的标记马来酰亚胺。该试剂可以使这些蛋白连接上近红外荧光团。然后，该复合物可以用于非入侵性的活体成像，来研究组织和生物体内的蛋白分布。

推荐手册：

蛋白与其他硫醇分子的马来酰亚胺标记

Cy® is a trademark of GE Healthcare.

General properties

Appearance:	>green powder
Molecular weight:	>807.46
Molecular formula:	C₅₁H₅₅ClN₄O₃
Solubility:	>soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	>NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	788
Extinction coefficient at excitation maximum, Lmol-1cm-1:	223000
Emission maximum, nm:	808

Lumiprobe Cy7.5-N-羟基琥珀酰亚胺酯

发表于2023年9月23日由上海金畔生物

Lumiprobe Cy7.5-N-羟基琥珀酰亚胺酯

英文名：Cyanine7.5 NHS ester
分子式：C49H52ClN3O4
分子量：782.41
品牌：lumiprobe
外观：green powder

订购货号	产品名称及规格
16020	Cyanine7.5 NHS ester, 1 mg
26020	Cyanine7.5 NHS ester, 5 mg
46020	Cyanine7.5 NHS ester, 25 mg
56020	Cyanine7.5 NHS ester, 50 mg
66020	Cyanine7.5 NHS ester, 100 mg

Cyanine7.5是一种近红外荧光染料，具有很长的发射光谱，是此类荧光衍生而来的活性胺产品。近红外照射很容易穿透组织因此常应用于体内成像领域。该产品可以用于标记含有氨基的小分子物质，比如蛋白和多肽，通过近红外光谱成像技术（NIR imaging）来示踪他们在有机体内的分布。中心聚亚甲基基团的增强的稳定性使得量子产率较其母结构Cy7.5® NHS提高20%。

推荐手册氨基分子的NHS酯标记

Cy® is a trademark of GE Healthcare.

General properties

Appearance:	green powder
Molecular weight:	782.41
Molecular formula:	C₄₉H₅₂ClN₃O₄
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	788
Extinction coefficient at excitation maximum, Lmol-1cm-1:	223000
Emission maximum, nm:	808

Product citations

Zhang, Z.; Cai, H.; Liu, Z.; Yao, P. Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative. Molecular Pharmaceutics, in press. doi:10.1021/acs.molpharmaceut.6b00188

Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J. Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice. Journal of Controlled Release, 2016, 235, 48–62. doi: 10.1016/j.jconrel.2016.05.049

Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M. Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants. International Journal of Nanomedicine, 2016, 11, 1213–1223. doi: 10.2147/IJN.S93324

Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T. Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain. Journal of Pharmaceutical Sciences, 2015, 104(7), 2334–2344. doi: 10.1002/jps.24497
Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J. The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small, 2015, 11(19), 2291–2304.201402870
Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J. Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry. Biomacromolecules, 2015, 16(11), 3574–3583. doi:10.1021/acs.biomac.5b01056
Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H. Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles. ACS Nano, 2014, 8(12), 12690-12700. doi: 10.1021/nn505688b
Graen, T.M.D.; Hoefling, M.; Grubmüller, H. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations. Journal of Chemical Theory and Computation, 2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A. Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels. Advanced Healthcare Materials, 2013, 2(7), 1028-1036. doi: 10.1002/adhm.201200343
Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34(36), 9124-9133. doi: 10.1016/j.biomaterials.2013.08.022